LESSER GALANGAL TABLE OF CONTENTS

[Study on the chemical components of Alpinia officinarum] Zhong Yao Cai. 1998 Jul;21(7):349-51.

Isolation and characterization of some antioxidative compounds from the rhizomes of smaller galanga (Alpinia officinarum Hance). J Agric Food Chem. 2003 Aug 13;51(17):4924-9.

[Chemical study of Alpinia officinarum] Zhong Yao Cai. 2000 Feb;23(2):84-7.

Inhibition of 5alpha-reductase activity by diarylheptanoids from Alpinia officinarum. Planta Med. 2003 Jan;69(1):72-4.

Isolation and structural elucidation of some glycosides from the rhizomes of smaller galanga (Alpinia officinarum Hance). J Agric Food Chem. 2002 Aug 14;50(17):4919-24.

ANTI INFLAMMATORY

Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids. Chem Pharm Bull (Tokyo). 1992 Feb;40(2):387-91.

Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci. 2001 Jan 12;68(8):921-31.

A diarylheptanoid from lesser galangal (Alpinia officinarum) inhibits proinflammatory mediators via inhibition of mitogen-activated protein kinase, p44/42, and transcription factor nuclear factor-kappa B. J Pharmacol Exp Ther. 2003 Jun;305(3):925-31. Epub 2003 Mar 06.

IDENTIFICATION OF 4-HYDROXY-2-NONENAL AS A POTENTIAL INDUCER OF CYCLOOXYGENASE-2 IN MACROPHAGES Originally published In Press as doi:10.1074/jbc.M409935200 on September 8, 2004 J. Biol. Chem., Vol. 279, Issue 46, 48389-48396, November 12, 2004

CONTRASTING VIEW

Experimental studies on antirheumatic crude drugs used in Saudi traditional medicine. Drugs Exp Clin Res. 1989;15(8):369-72.

ANTIOXIDENT

Screening of medicinal plant extracts for antioxidant activity. Life Sci. 2003 May 30;73(2):167-79.

Isolation and characterization of some antioxidative compounds from the rhizomes of smaller galanga (Alpinia officinarum Hance). J Agric Food Chem. 2003 Aug 13;51(17):4924-9.

Antioxidant properties of complexes of flavonoids with metal ions. Redox Rep. 2004;9(2):97-104.

TUMOR SUPPRESSIVE/CANCER PREVENTIVE

Flavonoids induce apoptosis in human leukemia U937 cells through caspase- and caspase-calpain-dependent pathways. Nutr Cancer. 2004;50(1):90-100.

ENHANCING CANCER DRUG EFFICACY

[The study on Rhizoma Alpiniae officinarum and other herbs as penetration enhancer for the permeation of 5-fluorouacil] Zhong Yao Cai. 2000 Nov;23(11):697-9.

EFFECT ON FATTY ACID SYNTHASE

Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3450-4.

Presence of fatty acid synthase inhibitors in the rhizome of Alpinia officinarum hance. J Enzyme Inhib Med Chem. 2003 Aug;18(4):349-56.

BINDS ANENOSINE RECEPTORS

Interactions of flavones and other phytochemicals with adenosine receptors. Adv Exp Med Biol. 2002;505:163-71.

CHEMOPROTECTION PROTECTS GENOTOXICITY

The bioflavonoid galangin blocks aryl hydrocarbon receptor activation and polycyclic aromatic hydrocarbon-induced pre-B cell apoptosis. Mol Pharmacol. 2000 Sep;58(3):515-25.

Anti-genotoxicity of galangin as a cancer chemopreventive agent candidate. Mutat Res. 2001 May;488(2):135-50.

The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor. Br J Cancer. 1999 Mar;79(9-10):1340-6.

Comparative inhibition of human cytochromes P450 1A1 and 1A2 by flavonoids. Drug Metab Dispos. 1998 Oct;26(10):989-92.

Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. Mutat Res. 2004 Jul 13;551(1-2):245-54.

ANTI ATHEROGENIC

5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone: a pancreatic lipase inhibitor isolated from Alpinia officinarum. Biol Pharm Bull. 2004 Jan;27(1):138-40.

3-Methylethergalangin isolated from Alpinia officinarum inhibits pancreatic lipase. Biol Pharm Bull. 2003 Jun;26(6):854-7.

NATURAL ANTIBIOTIC PROPERTIES

Assessment of the antibacterial activity of selected flavonoids and consideration of discrepancies between previous reports. Microbiol Res. 2003;158(4):281-9.

The antimicrobial activity of 3,5,7-trihydroxyflavone (GALANGIN) isolated from the shoots of Helichrysum aureonitens. J Ethnopharmacol. 1997 Aug;57(3):177-81.

Rutin-enhanced antibacterial activities of flavonoids against Bacillus cereus and Salmonella enteritidis. Biosci Biotechnol Biochem. 2002 May;66(5):1009-14.

Galangin expresses bactericidal activity against multiple-resistant bacteria: MRSA, Enterococcus spp. and Pseudomonas aeruginosa. FEMS Microbiol Lett. 2004 Nov 1;240(1):111-6.

ANTI VIRAL

Antiviral activity of galangin isolated from the aerial parts of Helichrysum aureonitens. J Ethnopharmacol. 1997 Apr;56(2):165-9.

Vancomycin resistance reversal in enterococci by flavonoids. J Pharm Pharmacol 2001 Dec;53(12):1729

ANTI FUNGAL

New antifungal substance from Alpinia officinarum Hance. Indian J Exp Biol. 1975 Jul;13(4):409.

Trypanocidal activity of Lychnophora staavioides Mart. (Vernonieae, Asteraceae). Phytomedicine. 2003;10(6-7):490-3.

ANTIEMITIC

Antiemetic principles of Alpinia officinarum. J Nat Prod. 2002 Sep;65(9):1315-8.

PROTECTION AGAINST DEVELOPMENT OF RESISTANCE TO CANCER DRUG EFFICACY

Herbal modulation of P-glycoprotein.Drug Metab Rev. 2004 Feb;36(1):57-104.

HISTORY OF LESSER GALANGAL

SERIE CODE:R16·Lesser Galangal Rhizoma P.E.(10:1) Alpiniae Officinarum P.E.What is Galangal (Alpiniae Officinarum.,Lesser Galangal)? What is Kaempferia Galanga. Arabic Khalanjan ginger?Origin,narrative history and modern application of Galangal and Lesser Galangal Rhizoma Extracts? Posted by michael derrida on March 10, 19104 at 23:00:14: